Mason County led 30-29 at the half, but the Lady Bluebirds outscored the Lady Royals 13-8 in the third quarter.
Neither team had a field goal in the fourth quarter.
Mason County hit five free throws fourth quarter, Highlands made four free throws in the final period to hang on for the win.
Both teams struggled from the field in the second half- Highlands was 5 of 17 (29.4%) and Mason County was 4 of 14 (28.6%).
Highlands scored 21 points off Mason County's 20 turnovers.
Whitney O'Mara led Mason County in scoring with 14 points.
The Lady Royals play the Boyd County Lady Lions Monday at 6 p.m. in the Martin Luther King Classic at Rowan County.
MC (11-3) Littleton 3, Frodge 4, Boone 8, O'Mara 14, McNutt 8, Moran 4, Reed 2